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The Number 1 Killer

Sepsis, the inflammatory reaction to an infection, causes one third to half of all cases of hospitalization deaths in the United States.

These are the statistics from a study published in the Journal of the American Medical Association. This study reviewed patients from two groups – one group was from the Kaiser Health group in northern California, that included 482,828 hospitalised patients 18 and up, in 21 hospitals between the years 2010-2012. The second group was 1,051 NIS hospitals that included 6.5 million hospitalized patients in 2010.

The scientists used two different methods in identifying sepsis cases. The direct method involved identifying the cases via the hospital code that was assigned to sepsis patients. However, because sepsis is not always recognized, the researchers added patients who suffered from an infection and organ failure (symptoms of sepsis).

Out of 14,208 cases of death in the Kaiser Group, 36.9%-55.9% (direct vs indirect method) were patients with sepsis. Out of 143,312 cases of death from the NIS group, the numbers are 34.7%-52%. Most of the patients were diagnosed with sepsis already in the emergency room.

What was interesting was that most of the cases of death were patients that arrived with a light case of sepsis. The reason for this is that, although there are clear treatment guidelines for difficult cases of sepsis, the treatment of light sepsis is not so clear. However, in order to reduce the amount of death, guidelines should be implemented to improve treatment of light cases of sepsis.